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Description
Its common to increases doses from the minimum after 2-4 weeks, eg.: Weeks 1-2: 2.5 mg, Weeks 3-6: 5 mg, Weeks 7-10: 7.5 mg ect.

LicataNVCristofaniRSalomonssonSWilsonKMKempthorneLVaizogluDet al
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As a result, the joint space width would be artificially altered, reflecting not the cartilage volume, but rather the degree of extension achieved

This can lead to excessive homocysteine or problems converting homocysteine into other compounds
