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ALC is widely distributed in mammalian tissues, including the brain, bloodbrain barrier, brain neurons, and astrocytes

9 Despite its severity, DN has received comparatively less attention in clinical research and therapeutic development than other diabetic complications, such as nephropathy and retinopathy, necessitating further research

asymptomatic patients are stage I, those with intermittent claudication (IC) are stage II, with rest pain stage III, and with trophic lesions stage IV [48]

The market is also influenced by the rising prevalence of cardiovascular and metabolic disorders, prompting higher adoption of L-Carnitine in therapeutic and dietary formulations

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*Correspondence: Qing-Rong Xia [email protected] This article was submitted to Mood and Anxiety Disorders, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers