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Future research must not only deepen our mechanistic understanding but also prioritize rigorous human studies to evaluate the safety and efficacy of lactate-targeted therapies

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These actions mitigate the impact of reactive oxygen species (ROS), which is stimulated by NADPH oxidase in inflamed skin, influencing the NF-B and AP-1 pathways

The venous system in the lower legs consists of a low-pressure superficial network connected by perforating veins to a high-pressure deep network

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