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Patients have high GT levels, normal cholesterol levels, and normal or mildly elevated BA concentrations

Another strategy focuses on identifying and targeting specific metabolic dependencies, a concept referred to as metabolic vulnerability therapy. In cell subpopulations with elevated OXPHOS activity and glutamine-driven TCA cycle flux, the combined use of glutamine metabolism inhibitors such as CB-839 with oxidative stress inducers, including doxorubicin or isothiocyanates, markedly increases intracellular ROS levels

BPC 157 was administered in a form of rectal solution given through an enema container at four different dose levels: 0.25 mg/kg, 0.5 mg/kg, 1 mg/kg, and 2 mg/kg