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selective C17,20-lyase inhibitors might avoid this effect CYP17 inhibitors that interfere with the androgen receptor (AR) might enhance clinical benefit and might result in increased compliance and reduced risk of drugdrug interactions compared with combined regimens Dual inhibitors of CYP17 and CYP11B1 might improve curative effects in patients with mutated ARs that are agonized by cortisol Dual inhibitors that target the C17,20-lyase activity of CYP17 and CYP11B2 might reduce the risks of cardiovascular complications associated with abiraterone use by mitigating increases in aldosterone levels Abstract As the first in class steroid 17-hydroxylase/C17,20-lyase (CYP17) inhibitor, abiraterone acetate (of which the active metabolite is abiraterone) has been shown to improve overall survival in patients with castration-resistant prostate cancer (CRPC)in those who are chemotherapy-naive and those previously treated with docetaxel

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Factors that may contribute to non-response include extremely chronic structural degeneration, product quality issues, improper storage or reconstitution, or individual variations in peptide metabolism

[DOI] [PubMed] [Google Scholar] 146.Nakamura S, Sugiyama S, Fujioka D, Kawabata K, Ogawa H, Kugiyama K

This assessment helps determine if the combination is appropriate and safe based on medical history, current medications, and lifestyle factors

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