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There are three enzymes contributing to UPP: E1 (Ub-activating enzyme) and E2s (Ub-carrier) prepare Ub for conjugation, but the main enzyme in the process is the E3 (Ub-protein ligase) which transfers the activated ubiquitin to the protein substrate to be degraded [66]

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Ferroptosis is a unique pattern of cell death hallmarked by iron-dependent phospholipid peroxidation (Jiang et al., 2021)

Follow-up studies can expand the research scope and investigate the therapeutic effects of HT in other types of diseases, to bring hope to more patients

One hypothetical explanation for producing these -glutamyl peptides could be associated with the unique enzymatic properties of -GCS that cause a futile cycle in cases of Cys deficiencies