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Moreover, DAG extracted from Sargentodoxa cuneate exerts its antioxidant effect by upregulating GPX4 expression and downregulating phosphoextracellular regulated protein kinases and HO-1 expression to counteract APAP-induced ferroptosis in hepatocytes (Liu et al., 2022)
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In chondrodystrophic (CD) dogs, IVD disease typically develops in the cervical or thoracolumbar spine at about 37 years of age, whereas in non-chondrodystrophic (NCD) dogs, it usually develops in the caudal cervical or lumbosacral spine at about 68 years of age

Acknowledgements The authors thank Ioav Cabantchik and Esther Meyron-Holtz for helpful feedback, and Tal Bigdary for help with figures

Hoogland, Netherlands Institute for Neuroscience, Netherlands Reviewed by Mark E
