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baumannii , a gene cluster for the metabolism of L-carnitine under aerobic conditions was predicted and bacterial growth on L-carnitine as the sole carbon and energy source was demonstrated ( lysR ), the energy-dependent import system BCCT and the two-component carnitine monooxygenase which catalyzes the oxygen-dependent cleavage of L-carnitine into TMA and MSA ( in vivo and in vitro reconstitution experiments clearly demonstrated the conversion of L-carnitine via MSA and D-malate to pyruvate, CO 2 and TMA

Indeed, glutamine-derived R-2-HG accumulates and prevents the differentiation of myeloblasts, resulting in uncontrolled growth of blood cells 122

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