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Key proteostasis pathways, including the UPS, ALP, HSPs, and UPR, are critical for regulating cellular homeostasis under these stress conditions (Fig

These findings suggest that the combined use of Pue and TSA exerts synergistic neuroprotective effects by activating the Nrf2/ARE pathway, inhibiting oxidative stress and inflammatory responses, providing experimental evidence for clinical application (143)

Cell death LEC were trypsinized 48 h post transfection and incubated with 2 g/mL propidium iodide (PI) (P4170, Sigma)

The frequency of monitoring is determined by the prescribing physician based on the protocol and individual response

Understanding these future directions will help researchers plan studies that contribute to the growing body of knowledge in metabolic science

Unlike beta-1 receptors in cardiac tissue or beta-2 receptors in smooth muscle, beta-3 receptors are predominantly expressed in adipose tissue and bladder, with limited cardiovascular effects