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Taking B12 too close to bedtime can be stimulating for some people and may make it harder to fall asleep or stay asleep. If you notice any change in your sleep after starting B12, simply move your dose earlier in the day and track how you feel

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The reason, in most cases, is straightforward: your digestive system has been surgically altered, and oral supplements can only do so much when the gut designed to absorb them has been rerouted or reduced

Metabolic Regulation

Methotrexate isnt recommended for people who already have chronic liver disease or who are heavy drinkers and have alcohol-related liver damage
