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The antioxidant properties of serum albumin will be discussed in the following chapter

This compromised mitochondrial function is driven by the combination of a shortfall in glutathione precursor amino acids (cysteine and glycine) and the accumulation of homocysteine (a toxic transsulfuration/glutathione biosynthesis pathway intermediate) [93]

Introduction Glutathione is a tripeptide found in many tissues at relatively high concentrations, namely 110 mM in cells, similarly to glucose, potassium, and cholesterol, with a critical role in several physiological processes, such as redox balance preservation, reduction of oxidative stress through detoxification from xenobiotic and endogenous compounds, and immune system modulation ( Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases ( Although the pathogenic role of oxidative stress in NAFLD pathogenesis is well established ( 2

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If the ratio becomes too low, the cell turns on NFkB [ref], which, in turn, initiates an inflammation cascade

Stenske, K.A