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All nitrogen-containing compounds synthesized in the body derive their nitrogen from amino acids cellular proteins, hormones (e.g., thyroxine, epinephrine, insulin), neurotransmitters, creatine phosphate, heme in hemoglobin and cytochromes, melanin, purine and pyrimidine bases

PMID: 42284407 Nat Struct Mol Biol RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth

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Pawlik M, Czarnecka AM, Koodziej M, Skowroska K, Wgrzynowicz M, Podgajna M, Czuczwar SJ, Albrecht J (2023) Attenuation of initial pilocarpine-induced electrographic seizures by methionine sulfoximine pretreatment tightly correlates with the reduction of extracellular taurine in the hippocampus

The effective metabolites in traditional Chinese medicine are biologically active chemical metabolites that define the therapeutic potential of natural medicines, characterized by specific chemical structures and physicochemical properties