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A recent study found that inhibiting PHB2-mediated mitophagy using PHB ligands (e.g., FL3) or shPHB2 effectively blocked cancer cell proliferation, revealing that targeting PHB2-mediated mitophagy is a promising strategy for cancer therapy [321]
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Individuals with ARTHS present with developmental delay, cognitive impairment (100% penetrance), delay or absence of speech (100%), facial dysmorphism (85%), feeding difficulties (78%), and neonatal hypotonia (76%) in a study of 76 individuals with KAT6A mutations (Kennedy et al, 2019)
J Photochem Photobiol B 170:256262
