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Huang et al., 2021)

The reduced activity and expression of sirtuin-1 eventually leads to cellular senescence

Chaney, W., Sundaram, S., Friedman, N

Melatonin acts not only as a free radical scavenger but also reduces nitric oxide (NO) production in mitochondria, maintains electron flow, and enhances oxidative phosphorylation efficiency

Similarly, RNAi-mediated knockdown of Sod2 leads to increased sensitivity to oxidative stress induced by PQ and a dramatic increase in adult-onset mortality (Kirby et al., 2002)

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGF1/Smad-Mediated Epithelial-to-Mesenchymal Transition