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In 2010, TYSABRI clinical trial data were used to define a new outcome: freedom from disease activity, 15 defined as absence of EDSS progression, relapse, or new/newly enlarging MS lesions
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In cortical neurons subjected to hypoxia/reoxygenation, HGF protects from apoptosis via the ERK pathway and, at a lesser extent, the PI-3K/AKT pathway (He et al., 2008)

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Proline oxidase, a proapoptotic gene, is induced by troglitazone: Evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms