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the goal of this study was to develop an AnglV-derived molecule that retained the pro-cognitive/anti-dementia activity of AnglV and Nle'-AnglV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain

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"Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects." The Journal of Clinical Endocrinology & Metabolism 81.12 (1996): 4249-4257

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