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Butyrate also reduces local intestinal inflammation and intestinal permeability through the stimulation of TJ expression and of mucin synthesis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 247.Liguori I, et al

Oral administration of meclofenoxate to rats (100 mg/kg, daily for 37 days) significantly improved memory impairment, and reduced neuronal damage, proinflammatory mediator levels, and oxidative stress to normal levels

With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)

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