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Hyper-homocysteinemia in PD patients may be aggravated due to the frequent administration of L-DOPA as a treatment to replenish dopamine loss

Eur J Pharm Biopharm 75:2632 Tsunoda S, Avezov E, Zyryanova A, Konno T, Mendes-Silva L, Melo EP, Harding HP, Ron D (2014) Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

RNA binding motif protein 45-mediated phosphorylation enhances protein stability of ASCT2 to promote hepatocellular carcinoma progression

33,34 JNK translocates to mitochondria, binds to SH3 homologyassociated Brutons tyrosine kinase (BTK) binding protein (Sab) on the mitochondrial membrane, and subsequently inactivates a proto-oncogene tyrosine-protein kinase (Src) in mitochondria, eventually leading to the dysfunction of the ETC and the increased release of reactive oxygen species (ROS)