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This local vs systemic placement is a documented research practice pattern, not a proven clinical instruction the evidence for meaningfully different outcomes by placement is limited and largely preclinical

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Treatment may include steroid injections into the joint, pain medications, and exercises to improve the strength and flexibility of the joint to prevent further damage or pain from occurring down the road

Discussions on manuscript contents: all authors

Pemetrexed is administered as a liquid solution that is injected into a vein over a 10-minute period

A full discussion on this process can be found in section III.C Verification of Worksheet S-3 Wage Data located in the FY 2024 IPPS final rule (87 FR 58961-58965)