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GSK3 is able to phosphorylate nebulin at two Ser sites in the C-terminal region of nebulin localized to the Z-disk, thus preventing the interaction of nebulin with neuronal Wiscott-Aldrich syndrome protein (N-WASP), a ubiquitously expressed member of the WASP family, which is involved in actin assembly (Figure 2)

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Given the known pleiotropy of ETC inhibition (for example, AMPK activation and ATP depletion), these approaches will probably require context-aware deployment rather than broad application