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These metabolites exert their effects not only within the gut but also across various organs due to their capacity to enter systemic circulation

[DOI] [PubMed] [Google Scholar] 137.Castano A.P., Mroz P., Hamblin M.R

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doi:10.1016/j.aquatox.2006.08

On the one hand, ROS induce oxidative damage to cysteine residues within the MutS complex (MSH2-MSH6 heterodimer), specifically impairing its ATPase-dependent DNA mismatch recognition capacity

The rs671 polymorphism of ALDH2 has been linked to elevated lung cancer risk among drinkers and is also associated with increased carotid intima-media thickness and blood pressure in hypertensive patients
