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Interleukin inhibitors Ustekinumab is an antagonist of the p40 subunit of pro-inflammatory cytokines interleukin-12 and interleukin-23, recently licensed for induction and maintenance therapy in CD and UC[9597]
GSH depletion increases oxidative stress and extensive carbonylation of proteins and modifies endogenous enzymes and proteins, resulting in impaired cellular function [56]
Clinical significance becomes apparent in performance assessment batteries
