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Fewer Digestive Side Effects Some people experience side effects from taking oral supplements, including: Upset stomach Nausea Constipation or diarrhea Bloating These side effects are often due to the fillers and binders used in pills or the digestive stress of breaking down high concentrations of nutrients

Sci Rep (2016) 6:33310

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Journal Clinical Pharmacology 56 (6), 635638

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Thus, by nature of its different affinity for the reduced folate carrier compared with folate receptors, the binding and transport of UMFA may selectively affect those tissues with exposed folate receptors that facilitate cellular entry and possibly signaling