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A further small study done recently on 10 paediatric patients similarly found that intranasal OH-Cbl normalised serum B12 levels in deficient patients ( Subcutaneous B12 Subcutaneous B12 is occasionally used, especially in patients with inborn errors of cobalamin metabolism, who need high pharmacological doses of B12 to maintain their B12-dependent metabolic pathways and related biochemistry within normal range

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Thomas R, Ponting DJ, Thresher A et al (2025b) Critical comparison of BMD and TD50 methods for the calculation of acceptable intakes for N-nitroso compounds