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[9] The European Food Safety Authority (EFSA) also confirms that absorption through oral route drops significantly when doses exceed 1-2 mcg, meaning high-dose tablets rely mostly on passive absorption, which is inconsistent

It may interfere with the treatments effectiveness

10.1093/ajcn/nqy072 [DOI] [PubMed] 33.Sezer RG, Akolu HA, Bozaykut A, zdemir GN (2018) Comparison of the efficacy of parenteral and oral treatment for nutritional vitamin B12 deficiency in children

This compound carries electrons in over 500 enzymatic reactions that extract energy from nutrients

The effect on truly "stubborn" subcutaneous fat (which is resistant due to higher alpha-2 adrenergic receptor density) is unclear

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