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After its conversion to acetyl-CoA , for example, pyruvate may serve as a precursor for fatty acid biosynthesis or for the synthesis of the amino acid alanine

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Li S, Yu Y, Yue Y et al (2013) Microbial infection and rheumatoid arthritis

doi: 10.1519/1533-4287(2003)017 2.0.co;2

Cells neutralize ROS via the action of various enzyme complexes, some of which ultimately result in the oxidation of reduced GSH to the oxidized form of glutathione, GSSG 20

This means that working on cancer cells alone will not achieve the goal of completely eliminating the tumor and new treatment strategies should consider the TME, that is, the surrounding immune cell components