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Not only does it further rob the body of the raw materials needed to make serotonin and melatonin, but the kynurenine pathway also produces neurotoxic metabolites like quinolinic acid

An elegant study showed that intracellular fumarate aggregation led to the succination of GPX4 at cysteine 93 (mono- and di-succination), which significantly reduced the enzymatic activity of GPX4 and sensitized cancer cells to FINs (Kerins et al., 2018)

Enzymatic activity modification of Na(+)/K(+) ATPase has been reported in anti-cancer agents induced oxidative stress 16

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This can lead to oxalate deposits in blood vessels, bones and body organs