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Participants were instructed to contact the study investigator immediately if they developed uncommon signs or symptoms or had any medical condition resulting in hospitalization or an emergency room visit

The Hadley 1989 publication in Life Sciences established Melanotan II as the benchmark melanocortin agonist against which all subsequent synthetic analogs have been compared, and its design principles directly informed the development of PT-141, setmelanotide, and other clinically investigated melanocortin peptides

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