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The POLG gene codes for the mtDNA polymerase gamma that is responsible for replication of human mtDNA, and mutations in POLG also cause mtDNA depletion

Chen P, Zuo H, Xiong H, et al

C., Walsh, A

TNF-, which is present in higher quantities in ERDS patients [85], blocks phosphorylation of insulin receptors, contributing to insulin resistance in these patients [86]

Up-regulation of RhoA/ROCK can inhibit the expression and activity of eNOS in penis (Laufs and Liao, 1998)