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Description

under stirring, and refluxed

Untargeted liquid chromatography-mass spectrometry metabolomics to assess drug-induced cholestatic features in HepaRG cells

Phase III: Elimination The final phase involves transporting these now-water-soluble complexes out of the cells and into the bile or urine for final elimination

In liver regeneration (LR) studies, after partial hepatectomy (PHx), HSCs exhibited high glycolytic metabolic flux and increased PFKFB3 expression in the liver and cells, and LR after PHx involved the activation of PFKFB3 in HSCs, as well as an increase in PFKFB3 to promote the production of the glycolysis product lactic acid, which promotes the proliferation of HSCs through the p38/ERK MAPK signaling pathway (76)