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Small molecule inhibitors such as RSL3 and ML162 mediate alkylation on GPX4 by binding to the selenium cysteine 46 residue by electrophilic alkyl chloride moieties (Eaton et al., 2020
2019;5(7):e02162
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Selenium is excreted through exhalation and urine in the form of small-molecule metabolites formed by sequential methylation 43,44
various approaches such as selenium supplementation and iodine-restricted diets have been proposed as disease-modifying treatments for earlier stages, and even thyroidectomy has been suggested for refractory cases of painful HT
doi: 10.3109/08916930109001960 104 KleinAKleinJChachamMKleinmanSShusterAPelegOet al
