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Retatrutide is an investigational engineered weight-loss peptide that switches on three metabolic receptors at once: GIP, GLP-1, and glucagon

Patel M, Lee HJ, Park S, Kim Y, Jeong B

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The addition of glucagon receptor activation introduces direct thermogenic and lipolytic effects that neither GLP-1 nor GIP agonism provides alone, creating a mechanism that, in some ways, bridges the gap between the direct fat-targeting approach of AOD 9604 and the systemic metabolic reprogramming of tirzepatide