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Urological cancers Kidney TNFRSF10B and POGLUT3 associated with kidney cancer and were also associated with other malignancies

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Therefore, the reestablishing of blood supply in reperfusion phase enhances several mechanisms that are more detrimental for renal parenchyma and include the burst of ROS, calcium overload, opening of the MPT pore, endothelial dysfunction and activation of coagulation and inflammatory response (88, 89)

Genetic variants affecting antioxidant enzyme production and mitochondrial efficiency could theoretically influence glutathione efficacy

doi: 10.3389/fbioe.2025.1729166 Received 21 October 2025 Revised 01 December 2025 Accepted 17 December 2025 Published 15 January 2026 Volume 13 - 2025 Edited by Ling Wang, Dalian Medical University, China Reviewed by Nicola Alessio, University of Campania Luigi Vanvitelli, Italy Yesuf Adem Siraj, Bahir Dar University, Ethiopia Updates Copyright 2026 Hu, Li, Hu, Shan, Tang, Jiang, Yi, Chen, Jin, Wang and Wang

Glutathione metabolism was less active in HGN samples, as evidenced by lower gene expression and reduced GSH metabolite content within this pathway