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Additionally, delivery by systemic administration has low bioavailability and high enzymatic degradation suggesting the use of nanoparticle carriers, viral vectored systems, and gene-editing methods to enhance endogenous BDNF production [315,316]

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Naguib S, et al

[PubMed] [Google Scholar] 49.Sergio W

4.4 Transcytosis mediated via adsorption The glycocalyx, which is made of heparan sulfate proteoglycans, imparts negative charges to the endothelial cell membrane of the BBB (69)