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Secondary hyperuricemia is also seen in individuals with myeloproliferative disorders undergoing therapy where there is excess cellular turnover (cell lysis leads to an accumulation of nucleotides) or in cases of Von Gierke disease or fructose intolerance, which increases substrate for PRPP synthesis

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Therefore, these results suggested that the appropriate concentration of Ag NPs could be designed for anti-inflammation and ROS-depletion against inflammatory disorders