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C: control/inactive group

Zhao, G

In high concentrations, however, some amino acids can be toxic to certain cells, as observed with Glu toxicity in neurons [45] and Cys toxicity in many types of cells, including neurons and hepatocytes

PEGylated lipids enhance the stability of LNPs, reduce immunogenicity, and extend their circulation time in the body [27].Lipid nanoparticles, including LNPs, possess the enhanced permeability and retention (EPR) effect, allowing them to accumulate in areas with increased vascular permeability, such as tumor sites, thus providing a significant advantage in tumor delivery

10.2217/rme.09.64 69 MemarM

doi: 10.1016/j.molmet.2022.101481 73 YuZPerssonHLEatonJWBrunkUT