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This Perspective discusses the emerging cellular roles of lysine lactylation, with a focus on the lactyl-CoA-independent pathway, and highlights the potential strategies of targeting lactylation for the treatment of associated human diseases.

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Subsequently, the effects of these drugs on glioma metabolism, proliferation, and apoptosis were explored in vitro and in vivo, using drug concentrations significantly lower than their respective IC50 values

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The blood-brain barrier (BBB) is a modulated anatomophysiological interface which separates and controls substance exchange between the blood and the brain parenchyma