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Pro-inflammatory cytokines induce mitophagy as a protective response, and mitophagy-deficient -cells accumulated dysfunctional mitochondria and had increased cell death, whereas overexpression of Clec16 rescued viability and mitophagy in human -cells (Sidarala et al., 2020)

However, in those categorized as poor risk due to adverse cytogenetics and molecular mutations, the response rate was only 30%

Safety concerns of polyphenols Numerous in vitro and in vivo toxicological studies have shown that polyphenols are safe agents

doi:10.1073/pnas.172398899

Cancer Evolution