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Peripheral immune cells account only for a small number of all cells that are present at demyelinating sites following cuprizone intoxication and their presence might indicate a role in demyelination that has not been explored yet

& Mochida, J

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Dose-escalation decisions in both phases are evaluated by a Safety Review Committee (SRC) , which assesses clinical, pharmacokinetic and safety data according to predefined stopping rules established in the study protocol

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Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin