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The differential metabolites were used for quantitative enrichment analysis

In hepatocellular carcinoma (HCC), resistance to sorafenib has been linked to downregulation of glutathione S-transferase Z1 (GSTZ1) [273], while in gastric cancer, the transcription factor ACTL6A promotes resistance by activating NFE2L2 and driving GSH biosynthesis [274]

R.GhorbaniZ.VahabizadF.MartellettiP.GhaemiA.et al

"In these situations, hair color can be restored with treatment of the underlying cause and following reversal, hair would then slowly gray at the genetically determined pace for aging." If you suspect an underlying health condition could be causing your hair to gray, visit a dermatologist that specializes in hair for an evaluation, Dr

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