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A wide gap between an effective dose and the highest dose tested does not straightforwardly translate into a wide human margin of safety, because interspecies scaling of peptides is not a simple body-weight multiplication

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Cell death was measured by counting maximum SYTOX TM Green positive cells normalised to starting cell confluence (B) from images generated by IncuCyte ZOOM software

J Am Chem Soc 130 (29), 9251-9253

2.3.3 Molecular pathogenesis and disease mechanisms The development of ALS is driven by several overlapping biological mechanisms that together cause motor neuron degeneration