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Nature (2004) This landmark Nature publication transformed understanding of TB-500's cardioprotective mechanisms by identifying integrin-linked kinase (ILK) as a key mediator of its cardiac effects

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However, its mechanism of increasing GH and IGF-1 can cause downstream effects that mimic elevated growth hormone levelsespecially at higher doses or with long-term use

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TB-500 has some GI data (thymosin beta-4 has shown effects in colitis models), but the evidence base isn't comparable to BPC-157's extensive GI portfolio