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In China, some TCM compounds have been approved as commercial Chinese polyherbal preparation (CCPP), while more TCM compounds are already in clinical trials (Table 3)

Crucially, sonographic stiffness quantification correlates with specific collagen disruption patterns, enabling mechanical phenotyping beyond conventional morphology 7

F-1,6-BP activates a positive feedback loop of key metabolic enzymes like PFK1, PI3K/Akt, and PFK2/PFKFB3, enhancing aerobic glycolysis to sustain effector T cell activity while inhibiting oxidative metabolism

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