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They facilitate the conjugation of GSH with electrophilic compounds, aiding in the elimination of harmful substances

Upregulation of type I IFN in SLE is thought to induce an IFN epigenomic signature, activating latent enhancers and bookmarking chromatin, reprogramming genes to be hyper-responsive, amplifying the inflammatory cascade (146148)

Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger HO, and protein chaperones

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The aging brain may develop a preference for ketones as an energy substrate in response to suboptimal glucose metabolism