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Mesylation of 5 (MsCl/CH 3 OH-Et 3 N-CH 2 Cl 2 /0 C), followed by lithium chloride treatment in DMF and hydrolysis (NaOCH 3 /CH 3 OH-CH 2 Cl 2 /room temperature) give the chloride 6 at a 95% overall yield

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It triggers the body to form fresh capillary networks, rapidly increasing blood flow to damaged or oxygen-starved tissues

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Neuroprotection and Nerve Regeneration: This is perhaps the most exciting and relevant mechanism for sciatica