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Four dose levels (3, 6, 15, and 30 mg/kg body weight) were given intraperitoneally

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PPHN is secondary to impaired or delayed relaxation of the pulmonary vasculature associated with a diverse group of cardiopulmonary pathologies such as meconium aspiration syndrome (MAS), congenital diaphragmatic hernia (CDH), congenital pneumonia, hypoxic ischemic encephalopathy (HIE / perinatal asphyxia), premature prolonged rupture of membranes (pPROM), respiratory distress syndrome (RDS) and underlying or associated congenital heart disease (CHD) (5, 6)

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Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

October 15, 2021 Understanding the Parts of Your Spine By Mark Wang, M.D