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FXR activation in macrophages may also indirectly reduce Th1 responses, as shown in models where FXR agonism diminished inflammation and IFN- + T cell populations (81)

doi: 10.1016/j.psj.2020.12.025 87 ZhangH.PertiwiH.HouY.MajdeddinM.MichielsJ

2019 Jan 1;58(1):42-6

In renal and hepatic fibrosis models, baicalin also attenuates EMT and restores epithelial phenotype markers, suggesting interruption of TGF-1driven transdifferentiation

Mitochondrial dysfunction in atherosclerosis

Therapeutic Implications and Future Directions The recognition of the interconnected roles of iron overload, cellular senescence, and fibrosis in endometriosis pathogenesis opens up new avenues for therapeutic intervention