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Modifications of cysteines even distal from the active site might however impact enzymatic activity, and for both PKM2 as well as for GAPDH, protein levels were prominently increased in tumor tissue (Fig

Interestingly, one study reported that GCN2 is dispensable for T cell anti-tumor activities in murine melanoma models, as T cell-specific GCN2 knockout neither impairs T cell responses against tumors, nor does it significantly affect FoxP3 expression in CD4+ T cells or IFN- expression in both CD4+ and CD8+ T cells in the tumor

138 , 30323037 (2013) Wang, S., Xiao, C., Jiang, L., Ling, L., Chen, X., Guo, X.: A high sensitive and contaminant tolerant matrix for facile detection of membrane proteins by matrix-assisted laser desorption/ionization mass spectrometry

Aging Cell 22 , e13740 (2023)

Assessment of oxidative DNA damage and repair at single cellular level via real-time monitoring of 8-OHdG biomarker