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Description

If D GI represents the amount of the drug in the GIT and D E represents the amount of the drug eliminated, the change in the amount of the drug in the body dD B /dt could be expressed as: The above curve could be classified into three segments (phases): , where the rate of drug absorption (dDThe absorption phase GI /dt) is greater than the rate of drug elimination (dD E /dt) , in which the rate of drug absorption (dDThe peak drug plasma concentration GI /dt) is equal to the rate of drug elimination (dD E /dt) , when the rate of drug elimination (dDThe elimination phase E /dt) is greater than the rate of drug absorption (dD GI /dt) It must be noted that, during the absorption phase and once the drug is available in the plasma, some of the absorbed drug may be eliminated, but absorption is major

Cancer Res 76, 29903002 (2016)

Ritonavir-induced carbamazepine toxicity

A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease prevention, novel drug design, and therapy