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Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10
Vinik AI, Casellini CM, Parson HK
The production of ROS radicals (Figure 1) starts by the one electron reduction of oxygen (O 2 ) to O 2 which under the influence of the enzyme superoxide dismutase is converted to H 2 O 2
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R.LebofskyM.NorrisH
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